POTENSI METFORMIN
SEBAGAI ANTI KANKER PAYUDARA
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Penulis:
Irma Yanti Rangkuti
Poppy Anjelisa Zaitun Hasibuan
Tri Widyawati
Yahwardiah Siregar
Yuandani
ISBN : 978-623-7297-03-1
——————————————————— Editor:
dr. Saiful Batubara, M.Pd
Penyunting:
Drs. Saiful Anwar Matondang, M.A., Ph.D
Desain Sampul Dan Tata Letak :
Syahlan, M.Pd
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Penerbit:
UISU Press
Redaksi :
JL. Sisingamangaraja – Teladan, Medan 20217
Telp. (061) 7869790 email : lppm@uisu.ac.id
Cetakan Pertama Juni 2019
© HAK CIPTA DILINDUNGI OLEH UNDANG-UNDANG
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Ibnu Nafis, Juni 2017, hlm 1-14 Vol. 6, No. 1
ISSN 2252-6870
Perbedaan Lama Waktu Alih Terapi Antibiotik pada Pasien Pneumonia Dengan Menggunakan Seftriakson dan Siprofloksasin di Rumah Sakit Haji Medan
Irmayanti Rangkuti* dan Sisilmonalisa
*Dosen Kopertis Wil. I DPK Fakultas Kedokteran UISU Medan
Fakultas Kedokteran UISU Medan, Jl. Sisingamangaraja XII No. 2A Medan
This research aims to know the differences a long time over the antibiotic therapy in patients of pneumonia by using seftriakson and ciprofloxacin in RS. Haji Terrain. The research is descriptive, using case studies of design series. Samples from the patient’s medical record pneumonia, research conducted in November – January 2017 respectively 73 samples that use seftriakson and ciprofloxacin.
The research results obtained by patients using seftriakson most apparent age 73-77 years (20.5%), male (54.8%), blood pressure <120mmHg (41,1%), respiratory frequency >20 x/minute (78.1%), pulse rate of 60-100 x/minute (61,6%), temperature of 36,5-37,5oC and > 37oC (39.7%), with clinical symptoms in the form of shortness of breath (82,2%), cough (71,2%), nausea (37.0%), fever (42.5%), vomiting (30.1%), leukocytes >11000/µl (87,7%), infiltrates (50,7%), hypertension (11,09%). Patients using ciprofloxacin most aged 70-79 years (20.5%), male (50,7%), blood pressure of 140-159mmHg (37.0%), respiratory frequency > 20 x/minute (70.7%), pulse rate of 60-100 x/minute (65.8%), temperature of 36.5 -37, 5oC (83,6%), shortness of breath (70.7%), cough (72,6%), nausea (20.5%), fever (43.8%), vomiting (30.1%), leukocytes >11000/µl (86,3%), infiltrates (54.8%), hypertension (15,1%). The average time over of therapy seftriakson 6,66 ± 2,38 day and ciprofloxacin 4,62 ± 3,10 day. Mann-whitney test was obtained p = 0.000 (p < 0.05) there is a difference in meaning between long time over seftriakson therapy with ciprofloxacin. Siproflokasasin had a great time over a shorter therapy compared to seftriakson.
Keywords: Long time instead of therapy, pneumonia, seftriakson, ciprofloxacin
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Ibnu Nafis, Desember 2015, hlm 59-65 Vol. 4, No. 2
ISSN 2252-6870
Perbedaan Kepatuhan Mengkonsumsi Obat Oral Anti Diabetes Satu Kali, Dua Kali dan Tiga Kali Sehari pada Penderita Diabetes Melitus Tipe 2
Irmayanti Rangkuti
Kopertis Wilayah I DPK Fakultas Kedokteran UISU Medan
Abstrack
Descriptive case studies have been done in the series of clinics Batang Kuis Deli Serdang district against 37 people are sufferers of diabetes mellitus (DM) type 2 for two months with the aim of knowing the difference sufferers taking medication compliance of oral anti diabetic (OAD) one, twice and three times a day. Sample determined in consecutive. Data collected in prospective primary data using.
The results showed most sufferers aged 53-55 years old, female, SMA level education. Twelve people consume OAD once a day, the average compliance 81.67 (SD 18.98). Seven people consume OAD twice a day, the average compliance 84.71 (SD 14.86). Eighteen people consume OAD three times a day, the average compliance 76.0 (SD 13.44). By using Anova test obtained p = 0397, there was no difference in average compliance consumes OAD once, twice and three times on patients suffering from type 2 DM.
Key words : Compliance, DM type 2, OAD
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International Journal of Engineering & Technology, 7 (4.15) (2018) 461-464
Effect of Addition of Composite Filler Volume on Ganoderma Boninense Mushroom Against Tensile Strength, Modulus of Elasticity, and Filler Distribution
Muhammad Rafiq Yanhar, Ahmad Bakhori Nasution, Siti Rahmah Sibuea, Abdul Haris Nasution
Faculty of Engineering, Universitas Islam Sumatera Utara, Medan, Indonesia *Corresponding author E-mail: rafiq@ft.uisu.ac.id
Abstract
This study aims to determine the effect of increasing filler volume of ganoderma boninense mushroom on tensile strength, modulus of elasticity, and distribution of the reinforcing particles. The composite reinforcement particle volume varies from 5%, 10%, 15%, and 20%. The mushroom is soaked with NaOH solution for 1 hour to remove dirt and sap that can reduce the bonds between matrix and particles. After that the mushrooms are made into mesh 50-sized particles using a blender with a rotation of 28,000 rpm. From the test results it can be seen that the highest tensile strength of 23.21 MPa is in the composite with a filler volume of 5%. The addition of particle volume to 10% makes the tensile strength slightly decrease to 21.04 MPa. The addition of filler volume to 15% and 20% causes the tensile strength to decrease to 20.55 MPa and 19.68 MPa. From the test results it can be seen that the lowest modulus of elasticity is in the composite with a filler volume of 5%. The addition of particle volume to 10% makes the modulus of elasticity rise to 83.15 MPa. The addition of filler volume to 15% and 20% causes the modulus of elasticity to increase to 126.77 MPa and 159.10 MPa. This shows that the more presence of ganoderma fungi in the composite causes the composite to become more elastic, thereby increasing the modulus of elasticity and decreasing tensile strength. The results of SEM photos showed the spread of mushroom powder at a volume of 5%, 10%, and 15% less evenly distributed, while in the filler 20% saw the spread of powder quite evenly.
Keywords: Ganoderma boninense mushroom, Tensile strength, Modulus of elasticity, Particle distribution
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International Journal of Engineering & Technology, 7 (2.13) (2018) 394-397
Fiber Laminate Adding Effect to Tensile Strength, Hardness, and Fault Surface of Teki Grass (Cyperus Rotundus) Composite
Muhammad Rafiq Yanhar, Muksin R Harahap, Ahmad Bachori, Suhardi Napid, Istu Sri Poneni, Abdurrozzaq Hasibuan
Faculty of Engineering, Universitas Islam Sumatera Utara, Medan, Indonesia *Corresponding author E-mail: rafiq@ft.uisu.ac.id
Abstract
The aim of this research is to know the fiber laminate adding effect to tensile strength, SEM photo, and hardness of teki grass (cyperus rotundus) composite specimen. Tensile and hardness test specimens were prepared by hand lay-up method with variations of 1, 2, and 3 fiber layers. Test results showed the highest tensile strength occurred in 1 layer fiber of 21.83 MPa and decreased in 2 layers of fiber and 3 layers of fiber of 17.95 MPa and 16.17 MPa. This is caused by random fibers that spread in all directions so that many fibers are not aligned with the tensile force. Addition of the fiber layer results in reduced resin volume so that the bond between fiber and matrix also decreases, which in turn will make the fiber cannot withstand tensile well. Analysis of SEM photographs also proves that the reduced volume of resin causes the bond between fiber and matrix to decrease resulting in cavities in 2 layer and 3 layers of composite. The results of the hardness test show that the addition of fiber layer decreases the hardness value. This is due to the soft grass fiber that is softer than the resin polyester, so that the added layer of fiber will reduce the hardness value.
Keywords: Fiber laminate, Tensile Strength, Hardness, Fault surface, Teki Srass Composite
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International Journal of Sciences: Basic and Applied Research (IJSBAR) ISSN 2307-4531
Correlation Between Tensile Test Specimen Surface Fault of Teki Grass (Cyperus Rotundus) Composite with Tensile Strength
Muhammad Rafiq Yanhara*, Abdul Haris Nasutionb
a,bDepartment of Mechanical Engineering, North Sumatera Islamic University, North Sumatera, Indonesia aEmail: mrafiqy7@gmail.com bEmail: aharisnst@gmail.com
Abstract
This study aims to determine the correlation between composite tensile strength with surface photo of 3 tensile specimens fault. In this research teki grass (cyperus rotundus) used as fiber, this type of fiber is selected because teki is agricultural weeds that have not been utilized to the maximum, difficult to eradicate and often found in the open fields. The length of fiber used are 1 cm, 2 cm, and 3 cm with each tensile strength of 23,99 MPa, 30,10 MPa and 18,91 MPa. SEM photo result of composite fault surface with a fiber length of 2 cm and tensile strength of 30.10 MPa indicates that the fiber is broken and there is no cavity between the matrix and the fiber. It can be concluded that the bond between the matrix and fiber is so good that make the tensile strength becomes the highest compared to the other 2 specimens. Photo of a composite fault surface with a fiber length of 1 cm and a tensile strength of 23.99 MPa shows that the fiber is broken, but there is little cavity between the matrix and the fibers. It can be concluded that the bond between the matrix and the fiber is not that good so that the composite tensile strength is lower than the 2 cm fiber. Composite fault surface photo with a fiber length of 3 cm has tensile strength of 18.91 MPa and shows that there is an open cavity along the fibers, this cavity informs that bond between matrix and the fibers doesn’t occur properly. Although from the photo shows that the fiber is broken, but the cavity still reduces the composite tensile strength to the lowest of 18.91 MPa.
Keywords : Photo SEM; Fault Surface; Composite; Tensile Strength.
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INTERNATIONAL JOURNAL OF SCIENTIFIC & TECHNOLOGY RESEARCH VOLUME 8, ISSUE 10, OCTOBER 2019 ISSN 2277-8616
Bending Stress Comparison Of Ganoderma Boninense Composites At Various Filler Volume, Mesh And Matrix
Muhammad Rafiq Yanhar, Siti Rahmah Sibuea, Ahmad Bakhori
Abstract
This study uses Ganoderma boninense mushroom as filler at different volume and mesh to determine composite flexibility level by bending tests. The mushroom are soaked with NaOH 5%for one hour, then dried in the oven for 12 hours, then made into powder according to the desired size. Filler volume varies from 5%, 10%, 15%, and 20%, while the mesh size is 20, 30, 40, and 50. The matrix used is epoxy and polyester resin. Mixture of filler and matrix is stirred evenly and then poured into a mold. Each specimen variable is made with 3 replications. The test results show that addition of filler volume increases the bending stress, both for polyester resin and epoxy resin composite matrix. The highest bending stress is found in polyester resin matrix composites, namely 49.67 MPa, or 32.7% greater than epoxy matrix composites (37.43 MPa). The addition of filler volume causes the composite to become more flexible and the flexibility level of this material is quite good to be used in a product. Further research can still be done by adding a filler volume above 20% to find out at what percentage of bending stress can reaches its maximum point. The addition of filler mesh size also increases bending stress both for polyester resin and epoxy resin composite matrix. The highest bending stress is found in polyester matrix composites, namely 38.33 MPa with mesh 50 or 9.67% greater than epoxy matrix composites (34.95 MPa). Further research can also be performed with mesh sizes above 50 even to the size of nano to determine the maximum point of bending stress.
Index Terms: Bending stress, filler volume, ganoderma boninense, matrix, mesh.
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IOSR Journal of Mechanical and Civil Engineering (IOSR-JMCE) e-ISSN: 2278-1684,p-ISSN: 2320-334X, Volume 13, Issue 3 Ver. I (May- Jun. 2016)
Tensile Strength and Density of Teki Grass (Cyperus Rotundus) Used as Materials for Fibre Composites with Fibre Angle Variation
Muhammad Rafiq Yanhar1A. Haris Nasution2
1, 2Department of Mechanical Engineering Faculty of Engineering Islamic University of North Sumatera (Indonesia)
Abstract
The primary purpose of this study is to determine the tensile strength and density) of the Indonesian term teki grass (Cyperus rotundus) in which this teki grass is used as the reinforcement materials for the production of fibre composite. The production process is carried out by using varieties of fiber directions ranging from 0°, 45°, 90°,and random.The methods in use is hand lay-up with 3 repetitions. Teki grass is chosen because it is easily found and has the following significances: biodegradable, harmless to health, available in nature in large quantities, and cost-efficient. Another reason because this plant is also an agricultural weed that is difficult to eradicate, not fully utilized, and often found in open field. While a matrix for fiber binder selected from epoxy resin material. From the test results it can be concluded that the variations in the direction of fibers effect on the tensile strenght of the composite. Average tensile strength of specimens with fibre directions of 0°, 45°, 90°, and random are 15.60 MPa, 18,69MPa, 30.11 MPa, and 22.79 MPa. In contrast, variations of fibre directions do not affect the density.
Keywords : Tensile strength, density, composite, hand lay up, fiber direction
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SIMULASI TEGANGAN PADA HELM INDUSTRI DARI BAHAN KOMPOSIT GFRP YANG MENDAPAT TEGANGAN INSIDEN SEBESAR 24,5 MPa
M. Rafiq Yanhar Jurusan Teknik Mesin, Fakultas Teknik, UISU
Abstrak
Penelitian ini mengetengahkan tentang verifikasi dengan menggunakan simulasi komputer dari pengujian helm industri dengan bahan komposit polimer GFRP yang mendapat beban impak kecepatan tinggi. Pemodelan helm dibuat dengan menggunakan software AutoCAD sedangkan distribusi tegangan yang terjadi pada helm dianalisa dengan software MSC NASTRAN 4.5. Data- data yang diperlukan untuk simulasi ini diperoleh dari beberapa pengujian yaitu : pengukuran massa jenis helm, uji statik untuk memperoleh sifat mekanik helm, dan uji impak untuk mengetahui besar tegangan insiden yang masuk ke dalam helm serta tegangan pada badan helm. Dengan beban impak sebesar 24,5 MPa maka selisih tegangan yang terjadi antara hasil eksperimen dan simulasi pada strain gage 15 mm dari titik impak adalah 5,6 %, sedangkan untuk strain gage 30 mm dari titik impak selisih tegangan adalah 2,6 %. Sehingga bila diambil rataratanya maka selisih tegangan antara eksperimen dan simulasi menghasilkan perbedaan sebesar 4,1 %.
Kata-kata Kunci: Simulasi, helm GFRP, tegangan insiden 24,5 MPa
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Mass Variation Effect of Teki Grass (Cyperus rotundus) Composite Against Tensile Strength and Density
Muhammad Rafiq Yanhar1 , A. Haris Nasution2
1, 2Department of Mechanical EngineeringIslamic University of North Sumatera (Indonesia)
Abstract
The primary purpose of this study is to determine the tensile strength using ASTMD 638 – 02a type IVB and density of teki grass (Cyperus rotundus) composite. The production process is carried out by mass variation of 2 gr, 3 gr, and 4 gr. Hand lay-up method with 3 repetitions are applied. Teki grass is chosen because it is easy to find and has some advantages biodegradable, harmless to health, available in nature in large quantities, and cost-efficient. Test result showed the largest tensile strength is 21,61 MPa at 2 gram mass fiber. Fiber addition to 3 gram and 4 gram cause tensile strength decreases to 18,51 MPa and 11,65 MPa. It happens because the fibers are random and spreads in all directions, so many fibers are undirectional with tensile force. Beside that fibers addition made matrix volume reduced and bond between fiber and matrix decreases, finally make fiber unable to hold the tensile force properly. It is recommended to use another type of ASTM D638 – 02a which has a larger narrow section like type I (13 mm) and type III (19mm) so specimens are not broken when removed from the mold, and there isn’t any decrease in tensile strenght. Density test showed that fiber mass does not significantly affect the density.
Keywords : Tensile strength, density, hand lay up, fiber mass
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